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October 20, 1934


JAMA. 1934;103(16):1236-1237. doi:10.1001/jama.1934.02750420048012

The idea of treating muscular dystrophy by the administration of glycine resulted directly from chemical analysis of the urine. The fact that the method is not yet definitely established as clinically successful in the present form of application does not detract from the essential importance of the fundamental observations. Creatinuria has been noted in many diseases that primarily or secondarily attack the muscular system. This led Thomas and his co-workers to investigate the effect of prolonged administration of glycine on the clinical course of progressive muscular dystrophies. In their preliminary report it was stated that the ingestion of from 15 to 20 Gm. of glycine daily raised the creatinuria of different cases by different degrees, depending on the extent of the original creatinuria. After some weeks the creatinurias were found to decrease despite the continuance of glycine. Coincident with the decrease in the creatinuria there was a rise in the

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