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August 16, 2016

Osteoporosis Therapy in Postmenopausal Women With High Risk of Fracture

Author Affiliations
  • 1Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia
  • 2Endocrine Research Unit, San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco
  • 3Associate Editor, JAMA
JAMA. 2016;316(7):715-716. doi:10.1001/jama.2016.11032

Forty-six percent of white women 50 years of age and older will sustain an osteoporotic fracture during their remaining lifetime.1 Vertebral fractures are the most common osteoporotic fracture; two-thirds are asymptomatic, presenting as incidental findings on radiographs.2 After an initial hip or vertebral fracture, risk of a second fracture more than doubles, with highest risk in the first year.3 Fall prevention, weight-bearing exercise, and adequate intake of calcium and vitamin D are cornerstones of fracture prevention.4 However, medical therapy is often required to treat osteoporosis. Patients who have already sustained a fragility fracture of the hip or spine should be considered for medical therapy to prevent additional fractures, even without bone mineral density (BMD) testing.4

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