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Physicians are finding a wider range of congenital abnormalities beyond microcephaly that appear to be associated with Zika virus infection in utero, observations that suggest the presence of a new congenital syndrome, according to a report from the World Health Organization (Costello A et al. Bull World Health Org. 2016;94:406-406A). Zika-related abnormalities include craniofacial disproportion, spasticity, seizures, eye problems, irritability, brainstem dysfunction, and neurological problems that range in severity are being observed in infants born with normal head circumference. Zika infection may also cause problems in cardiac, digestive, and genitourinary systems in infants. Antenatal and postnatal histories as well as follow-up data, laboratory findings, and neuroimaging results will be used to define the new syndrome.
Friedrich M. More Insights Into Zika Virus Infection and Birth Outcomes. JAMA. 2016;316(7):702. doi:10.1001/jama.2016.10895