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Comment & Response
August 23/30, 2016

Online Intervention for Prevention of Major Depression—Reply

Author Affiliations
  • 1Department of Clinical Psychology and Psychotherapy, Friedrich-Alexander-UniversityErlangen-Nuremberg, Erlangen, Germany
  • 2Division of Online Health Training, Leuphana University, Lueneburg, Germany
  • 3Department of Clinical, Neuro, and Developmental Psychology, Vrije Universiteit, Amsterdam, the Netherlands
JAMA. 2016;316(8):881-882. doi:10.1001/jama.2016.9586

In Reply We agree with Dr Anghelescu that it is remarkable that a major depressive episode can be prevented in people with subthreshold depression with a brief 6-session intervention. However, although this study was the first one showing that it is possible to prevent a major depressive episode using a web-based guided self-help intervention, evidence is accumulating that this can be achieved with brief face-to-face interventions.1

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