November 3, 1934


JAMA. 1934;103(18):1380. doi:10.1001/jama.1934.02750440040014

The question of the nature of antibodies is of practical as well as theoretical importance. The more complete the knowledge of their nature, the more favorable the conditions for preparing them for therapeutic and diagnostic use. Insight into the mechanisms of immunity is dependent in large measure on an understanding of the composition and structure of antibodies. Many attempts have been made to separate the antibodies from the other constituents of serum. On variation in the salt concentration of serum the antibodies in general come down with the globulin fraction no matter what method is used, and as a rule antibodies are not associated with or limited to any particular form of globulin thus prepared. The methods now in use for the concentration and purification of diphtheria and other antitoxins are based on the salt precipitation of serum globulins. Under the proper conditions, alcohol precipitates proteins as well as antibodies

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