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November 3, 1934


JAMA. 1934;103(18):1381-1382. doi:10.1001/jama.1934.02750440041016

The limitations for the use of artificial fever therapy are becoming more clearly defined. A recent report of Simpson1 is based on the use of the Kettering hypertherm, a simple air conditioned cabinet with which it is possible to elevate the patient's temperature rapidly and to maintain it at the desired level for an extended period. The use of this form of hyperpyrexia has been largely concentrated on syphilis. One hundred and seventeen syphilitic patients were treated, and in eighty-seven the course was completed. The best results were obtained by combining antisyphilitic therapy (e. g., bismuth compounds, iodobismitol or tryparsamide) with at least fifty hours of sustained fever at approximately 106 F. The sessions of fever were usually given weekly for ten weeks, with five hours of sustained fever at each session. The antisyphilitic drug was injected half an hour before each session of fever. After completion of this

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