Spontaneous and frequent epistaxis is a common manifestation of hereditary hemorrhagic telangiectasia (HHT). In a randomized placebo-controlled trial involving 80 patients with HHT, Dupuis-Girod and colleagues assessed the efficacy of different doses of intranasal bevacizumab—an angiogenesis inhibitor—on nosebleed duration. The authors report that compared with placebo, treatment with bevacizumab nasal spray—3 doses of 25 mg, 50 mg, or 75 mg per spray administered at 14-day intervals for a total treatment duration of 4 weeks—did not reduce epistaxis duration in the 3 consecutive months after the end of treatment.
Highlights. JAMA. 2016;316(9):897-899. doi:10.1001/jama.2015.14458