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Lab Reports
September 6, 2016

Liquid Biopsy to Evaluate Efficacy of Cancer Therapy

JAMA. 2016;316(9):917. doi:10.1001/jama.2016.12068

Using patient-derived circulating tumor cell (CTC) cultures obtained from blood-drawn liquid biopsies, a team led by investigators at the Singapore–Massachusetts Institute of Technology Alliance for Research and Technology Centre has developed a new approach to assess the effectiveness of cancer treatment within 2 weeks (Khoo BL et al. Sci Adv. 2016;2[7]:e1600274).

The technique uses a microfluidic assay integrated with 2 components: custom-designed tapered microwells for cutting and a gradient generator to carry out drug screening. Cultures are maintained as multilayered clusters to better reflect the in vivo state of a tumor.

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