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Using 3D textile manufacturing methods and gene delivery techniques, investigators from North Carolina and Missouri have engineered anatomically shaped, functional cartilage constructs that deliver anti-inflammatory therapy to protect diseased or injured joints from inflammation (Moutos FT et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1601639113 [published online July 18, 2016]).
The team fabricated large hemispherical scaffolds from 3D poly(ε-caprolactone) fibers, an FDA approved biomaterial, woven into a porous structure. These scaffolds were seeded with human adipose-derived stem cells (hASCs), recreating the properties of native hip joint surfaces while encouraging cell infiltration, growth, and differentiation.
Hampton T. Researchers Develop Tissue-Engineered Cartilage. JAMA. 2016;316(9):917. doi:10.1001/jama.2016.12070