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April 11, 1942

PROPYLENE GLYCOL A MENSTRUUM FOR SODIUM SULFATHIAZOLE

JAMA. 1942;118(15):1317. doi:10.1001/jama.1942.02830150053027

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Abstract

To the Editor:—  In Queries and Notes in a recent issue of The Journal (February 14, p. 567) one reads the reply to the disturbing question concerning the safe concentration of sodium sulfathiazole when used in medicating the nasal mucosa. As was so well stated, sodium sulfathiazole is not free of undesirable reactions because of the irritating properties associated with its alkalinity. Aqueous solutions of sodium sulfathiazole vary in pH from 10 to 11 and may become yellow on standing, especially when unprotected from daylight. To obviate the strong alkalinity, irritating properties and deterioration of such solutions, we have dissolved various sulfonamides in propylene glycol (Modern Hospital57:106 [July] 1941; J. Indiana M. A., to be published in April). The most useful of these propylene glycol preparations have been a 3 per cent solution of sulfathiazole, a 3 per cent solution of sulfapyridine and a 10 per cent

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