[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.205.87.3. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
April 18, 1942

SEVERE ARSENICAL REACTION ENCOUNTERED IN THE FIVE DAY TREATMENT FOR EARLY SYPHILIS

Author Affiliations

Chicago
From the Department of Dermatology, Cook County Hospital, and the Department of Public Health, State of Illinois, R. R. Cross, M.D., Director, and Herman Soloway, M.D., Venereal Disease Control Officer; with the cooperation of the United States Public Health Service.

JAMA. 1942;118(16):1368. doi:10.1001/jama.1942.62830160001007
Abstract

This is to record the first serious reaction affecting the kidneys, liver and heart from the use of mapharsen in the treatment of early syphilis by the five day massive dose method. One of the significant facts noted in our experience of 348 patients treated by this method, and among the 1,1501 or more patients treated similarly by the Middle Western Cooperative Group, has been the lack of serious damage to important parenchymatous organs. There have been reports of several cerebral accidents,2 some of them fatal, and minor side effects have been encountered frequently—nausea, emesis, headache, fever, painful arms and toxic eruptions. Aside from transitory albuminuria and a slight elevation of the icteric index, however, there have been no reports of a reaction in which the toxic manifestations were those of an acute glomerulonephritis, anuria, uremia, hepatitis, ileus and pericarditis.

REPORT OF CASE  A Negro aged 23 had

First Page Preview View Large
First page PDF preview
First page PDF preview
×