This is to record the first serious reaction affecting the kidneys, liver and heart from the use of mapharsen in the treatment of early syphilis by the five day massive dose method. One of the significant facts noted in our experience of 348 patients treated by this method, and among the 1,1501 or more patients treated similarly by the Middle Western Cooperative Group, has been the lack of serious damage to important parenchymatous organs. There have been reports of several cerebral accidents,2 some of them fatal, and minor side effects have been encountered frequently—nausea, emesis, headache, fever, painful arms and toxic eruptions. Aside from transitory albuminuria and a slight elevation of the icteric index, however, there have been no reports of a reaction in which the toxic manifestations were those of an acute glomerulonephritis, anuria, uremia, hepatitis, ileus and pericarditis.
REPORT OF CASE
A Negro aged 23 had
Rattner H, Falk AB. SEVERE ARSENICAL REACTION ENCOUNTERED IN THE FIVE DAY TREATMENT FOR EARLY SYPHILIS. JAMA. 1942;118(16):1368. doi:10.1001/jama.1942.62830160001007