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March 17, 1928


JAMA. 1928;90(11):869-870. doi:10.1001/jama.1928.02690380053026

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Combined Treatment of Malignant Diphtheria with Diphtheria Antitoxin and Streptococcus Antitoxin  During the past two years in Berlin there has been an increase in the number of diphtheria cases and in the number of cases that have terminated fatally. Researches have shown that in half of the observed malignant cases highly virulent streptococci are present not only in the pharyngeal membrane but also in the blood. In the municipal hospital both diphtheria serum and streptococcus antitoxin have, of late, been injected. Before the Berliner Medizinische Gesellschaft, Professors Finkelstein and Fritz Meyer recently reported the results of such treatment. Meyer expressed himself as follows: Bacteriologic researches on malignant (toxic, septic) pharyngeal diphtheria reveal, in 50 per cent of all cases, hemolytic streptococci in large quantities. In such researches both the Löffler serum and the blood plates should be taken into account. The streptococci form a poison that, at the site of

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