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April 25, 1942


Author Affiliations

Newton, Mass.

JAMA. 1942;118(17):1449-1450. doi:10.1001/jama.1942.62830170001007

There are many so-called patent medicines advertised and marketed in the United States. The new Federal Food, Drug and Cosmetic Act requires that the ingredients of these products be listed on the package. Carter's Little Liver Pills is a nationally advertised product. It is stated on the package marketed that the pills contain podophyllum resin and Curaçao Aloe. The amount of each drug in each pill or in the entire package is not stated.

O'Donovan1 stated that podophyllum resin, known as podophyllin, is extracted from the root of Podophyllum peltatum L. by percolation with 90 per cent alcohol, precipitation of the resulting tincture in water aciduated with hydrochloric acid, washing and drying. It is a pale yellow to deep orange-brown amorphous powder, soluble in 90 per cent alcohol and in ammonia and partly soluble in ether. The resin yields a percentage of a crystalline substance known as podophyllotoxin C

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