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April 25, 1942


Author Affiliations


JAMA. 1942;118(17):1514. doi:10.1001/jama.1942.02830170092024

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To the Editor:—  The article by Dr. Frederic W. Taylor on the misuse of sulfonamide compounds, which appears in the March 21 issue of The Journal, paints a discouraging picture with regard to the local use of these drugs. Although his experimental observations are no doubt true, from a practical point of view and experience with the clinical use of these drugs, the advantages of their local use, it seems to me, far outweigh the disadvantages. I have recently been interested in the use of sulfathiazole prepared in the microcrystalline form. The details of the preparation will be reported elsewhere. I wish to state here, however, that the crystals are of uniform size and are extremely small. The advantage of this type of preparation is the fact that a considerably greater surface exposure is permitted so that the drug, although no more soluble, goes into solution more readily.When the

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