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To the Editor:—
The ready availability of cevitamic acid (ascorbic acid) in pure crystalline form has naturally suggested its parenteral administration in solution in acute scorbutic conditions (Schultzer, Paul: Lancet2:589 [Sept. 9] 1933. Bauke, E. E.: München. med. Wchnschr. 81:1240 [Aug. 10] 1934). In order to prevent untoward local reactions from such administration, which may be attributed to the drug, certain pertinent factors should be called to the attention of physicians.Cevitamic acid is a relatively strong acid and on dissolving in water yields a solution of low pH value (about 3.4). Its acid solution injected intravenously would be partially neutralized by the buffer alkalis of the blood, but on subcutaneous, intramuscular or intradermal injection such neutralization might not be quick enough to prevent the sclerosing effect of a strong acid solution. We have observed skin sloughs in mice, rats, guinea-pigs and rabbits, within three hours
Fisher BH, Leake CD. THE PARENTERAL ADMINISTRATION OF CEVITAMIC ACID (ASCORBIC ACID) SOLUTIONS. JAMA. 1934;103(20):1556. doi:10.1001/jama.1934.02750460060024