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To the Editors:—
Editorial comment recently appeared (The Journal, March 21, p. 981) on zinc peroxide and sulfonamide derivatives in the treatment of gas gangrene. This called attention to the work of F. L. Meleney (Ann. Surg.101:997 [April] 1935; 109:881 [June] 1939; U. S. Nav. M. Bull.40:53 [Jan.] 1942) in showing the effectiveness of a 40 per cent watery suspension of zinc peroxide in preventing gas gangrene when applied to wounds infected with gas producing organisms. This has been confirmed by G. B. Reed and J. H. Orr (War Med.2:79 [Jan.] 1942) and has been extended by them to include the use of sulfathiazole. They state that sulfathiazole is superior to other sulfonamide derivatives for this purpose. The latter opinion is at variance with the experience of surgeons at Pearl Harbor, who feel that there is less foreign body reaction in the wound
Leake CD. ADVANTAGES OF BENZOYL PEROXIDE OVER ZINC PEROXIDE OR SULFONAMIDES IN TREATING WOUNDS OR BURNS. JAMA. 1942;119(1):101. doi:10.1001/jama.1942.02830180103023