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November 24, 1934

Current Comment

JAMA. 1934;103(21):1626-1627. doi:10.1001/jama.1934.02750470048015

THE VITAMIN C CONTENT OF HUMAN TISSUES  The recent isolation of vitamin C, its identification and its synthesis have opened a new field for the investigation of the physiologic rôle of this substance in the organism. Harris and his co-workers1 in England determined by chemical methods its rate of excretion in the urine following oral ingestion. It was suggested that this method might serve as a means of determining latent scurvy in patients before detectable clinical signs appear. More recently Yavorsky, Almaden and King2 in this country have assayed also by chemical means the vitamin C content of various human tissues obtained at necropsy. Material was obtained from sixty-seven individuals ranging in age from birth to 70 years. Thirty-one were less than 10 years old; of these the vitamin C content of the tissues was so low in four that latent scurvy was evident. In six of the

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