November 24, 1934

Current Comment

JAMA. 1934;103(21):1626-1627. doi:10.1001/jama.1934.02750470048015

THE VITAMIN C CONTENT OF HUMAN TISSUES  The recent isolation of vitamin C, its identification and its synthesis have opened a new field for the investigation of the physiologic rôle of this substance in the organism. Harris and his co-workers1 in England determined by chemical methods its rate of excretion in the urine following oral ingestion. It was suggested that this method might serve as a means of determining latent scurvy in patients before detectable clinical signs appear. More recently Yavorsky, Almaden and King2 in this country have assayed also by chemical means the vitamin C content of various human tissues obtained at necropsy. Material was obtained from sixty-seven individuals ranging in age from birth to 70 years. Thirty-one were less than 10 years old; of these the vitamin C content of the tissues was so low in four that latent scurvy was evident. In six of the

First Page Preview View Large
First page PDF preview
First page PDF preview