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Comment & Response
September 20, 2016

Timing of Initiation of Renal Replacement Therapy in Critically Ill Patients With Acute Kidney Injury

Author Affiliations
  • 1Beijing Anzhen Hospital, Capital Medical University, Beijing, China
JAMA. 2016;316(11):1212-1213. doi:10.1001/jama.2016.11320

To the Editor Timing of initiation of renal replacement therapy (RRT) in patients with severe acute kidney injury (AKI) remains controversial. Several well-designed, randomized clinical trials have been published or are ongoing.14 The single-center Early vs Late Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury (ELAIN) trial found an early strategy of initiating RRT compared with a delayed strategy reduced mortality in patients who were critically ill.1

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