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JAMA Clinical Evidence Synopsis
September 27, 2016

Blood Measurement of Carcinoembryonic Antigen Level for Detecting Recurrence of Colorectal Cancer

Author Affiliations
  • 1University of Oxford, Oxford, England
  • 2University of Leeds, Leeds, England
JAMA. 2016;316(12):1310-1311. doi:10.1001/jama.2016.11212

Clinical Question  What is the trade-off between sensitivity and specificity at specific carcinoembryonic antigen (CEA) thresholds for detecting recurrent colorectal cancer?

Bottom Line  To detect colorectal cancer recurrence, the sensitivity of CEA ranges from 68% for a threshold of 10 µg/L to 82% for a threshold of 2.5 µg/L and the specificity ranges from 97% for a threshold of 10 µg/L to 80% for a threshold of 2.5 µg/L.