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December 15, 1934


JAMA. 1934;103(24):1853-1854. doi:10.1001/jama.1934.72750500009010

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THERAPY OF CHANCROID AND BUBO DIAGNOSIS  A few days after exposure there is a soft, flabby erosion and then an ulcer, which is inflammatory, painful and tender. It may be single or multiple and has an irregular, undermined border and an uneven base covered by a dirty purulent exudate. The streptobacillus of Ducrey can be found in the exudate.Chancroid and its bubo must be differentiated from (1) syphilitic infection, (2) fusospirochetal balanitis, (3) granuloma inguinale, (4) lymphogranulomatosis inguinalis, (5) herpes progenitalis and (6) epithelioma.

  1. Every ulcer on the genitalia of a sexually active person should be considered a syphilitic chancre until proved otherwise and no treatment should be addressed to it until an absolute diagnosis has been made. In untreated cases, dark field examination for Spirochaeta pallida is positive in more than 90 per cent of syphilitic cases even on first examination. If the ulcer has received treatment,

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