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December 29, 1934


JAMA. 1934;103(26):2031-2032. doi:10.1001/jama.1934.02750520033013

Recent investigations of the influence of amino acid therapy on the unbalanced creatine-creatinine metabolism associated with certain types of myopathies have yielded interesting results. These appear to be of particular significance when the alterations in creatinuria are related to the favorable prognosis in this clinical syndrome. Gibson and Martin1 and Brand, Harris, Sandberg and Ringer2 were among the first to recognize the importance of glycine3 in their investigations of the origin of creatine. The latter workers showed that the ingestion of this amino acid or of gelatin, which is high in glycine, by patients with progressive muscular dystrophy was followed by a large increase in the creatinuria. This significant relationship between glycine, a substance that the normal person can readily synthesize, and creatine, which has been demonstrated to play an important part in muscle function, suggested to several investigators that the prolonged administration of the amino acid

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