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July 11, 1942


JAMA. 1942;119(11):885-886. doi:10.1001/jama.1942.02830280031012

Lacassagne,1 utilizing a strain of mice whose females developed breast carcinoma in high proportion, transplanted ovaries into previously castrated males on the supposition that mammary cancer did not develop in the males of the strain because of excessive atrophy of the mammary elements. Of 12 animals thus treated, none developed breast carcinoma at the end of one year. The same failure to produce cancer in this manner attended the experiments of Loeb, of Cori and of Murray. Lacassagne injected weekly into mice 10 to 18 days old 0.05 cc. of a solution in oil of 0.6 mg. of crystalline estrone benzoate. All of the 3 males and 1 of the 2 females thus treated exhibited a typical mammary adenocarcinoma in from four to five months. This was apparently the first experimental production of mammary cancer in mice. Workers in this field were now confronted with the problem of determining

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