[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 774
Citations 0
Lab Reports
October 4, 2016

Imaging Epigenetics in the Human Brain

JAMA. 2016;316(13):1349. doi:10.1001/jama.2016.13667

Researchers at Massachusetts General Hospital have tested a novel positron emission tomography (PET) radiotracer that reveals gene expression patterns regulated by chromatin-modifying enzymes within the brain in a first in-human study (Wey H-Y et al. Sci Transl Med. 2016;8[351]:351ra106). Alterations in such epigenetic activity has increasingly been associated with the pathophysiology of Alzheimer disease, schizophrenia, depression, addiction, among others.

The method uses the radiochemical [11C]Martinostat, an imaging probe that selectively binds certain histone deacetylase (HDAC) isoforms. In general, HDACs function to silence gene expression. Although several HDAC inhibitors are being studied for the treatment of neurodegenerative disorders, investigators have been unable to assess HDAC expression in the living brain.

First Page Preview View Large
First page PDF preview
First page PDF preview