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Investigators have sequenced the DNA and RNA of vascular and metabolic tissues from patients to provide new insights into the tissue-specific effects of genetic variants associated with cardiovascular disease (CVD) (Franzén O et al. Science. 2016;353:827-830). The methods used in these analyses go beyond genome-wide association studies to reveal tissue-specific genes and regulatory elements that contribute to CVD.
The analyses were conducted on samples from 600 patients with coronary artery disease who were enrolled in the Stockholm-Tartu Atherosclerosis Reverse Networks Engineering Task (STARNET) study, which was launched in 2007. Samples were isolated from blood, the internal mammary artery, the aorta, subcutaneous fat, visceral abdominal fat, skeletal muscle, and the liver.
Hampton T. Reservoir of Genetic Data Related to Cardiovascular Disease. JAMA. 2016;316(13):1349. doi:10.1001/jama.2016.14159