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January 19, 1935

Die Kinder männlicher und weiblicher Morphinisten (Frage der Keimund Fruchtschädigung, Erbgang der Psychopathie)

JAMA. 1935;104(3):242-243. doi:10.1001/jama.1935.02760030074026

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The author reviews experimental proof of alterations of hereditary factors in animals and plants due to environment; for instance, mutations characterized by changes in the eye, wings and body color in the fruit fly (Drosophila) following exposure to x-rays. Changes in lower life following exposure to solutions of chemicals have been less pronounced. Proof of mutations in man due to certain environmental agencies, such as alcohol, is questioned. He considers morphine addiction a fertile field for this type of genetic analysis. The sexual functions are usually inhibited and the toxic period of the subject's lifeis sharply separated from the normal.

A total of 1,929 adult addicts, 1,348 male and 581 female, were genetically analyzed. The children produced before or after (115) and during the period of addiction (280) were examined for mental and physical defects. Those born during the period of addiction of one or both parents were 69.6 per

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