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The author, who for many years has been making a clinical and biochemical study of epilepsy, utilizing a large material, has in this short monograph condensed his work and that of others into such a form as to be readily usable. He has applied the newer methods of clinical testing of the vegetative nervous system, and metabolic and biochemical studies of the regulatory functions of the central vegetative system to the epileptic patient. In the clinical manifestations he finds evidences of disturbances of the sympathetic system. He finds an altered water and salt metabolism, marked variations in blood calcium and sodium content, a definite disturbance in the acid-base relationship, and an abnormal serum albumin picture. None of these abnormalities show much degree of constancy as to the type. Frisch considers the abnormal metabolism as the dispositional factor in the convulsive tendency because it plays on the irritability of the ganglion
Das "Vegetative Syste" der Epileptiker.. JAMA. 1928;90(20):1657-1658. doi:10.1001/jama.1928.02690470063044