Empirical antifungal therapy is often used in the treatment of intensive care unit (ICU)–acquired sepsis—despite a lack of evidence that the practice improves outcomes. In a multicenter placebo-controlled randomized clinical trial involving 260 critically ill adults with unresolved sepsis (despite treatment with broad-spectrum antibiotics), Candida colonization at multiple sites, and multiple organ failure, Timsit and colleagues found that 14 days’ treatment with micafungin did not increase fungal infection–free survival at day 28. In an Editorial, Siddharthan and colleagues discuss empirical vs targeted treatment of invasive fungal infections.
Highlights. JAMA. 2016;316(15):1515-1517. doi:10.1001/jama.2015.14536