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Global Health
October 18, 2016

Congenital Brain Abnormalities From Zika Infection

JAMA. 2016;316(15):1537. doi:10.1001/jama.2016.14955

A range of brain abnormalities that can arise in fetuses and newborns from congenital infection with the Zika virus are illustrated in series of radiographs in a recent report from Brazilian and US researchers published in Radiology.

In this retrospective review, the investigators analyzed prenatal and postnatal images of 17 fetuses or newborns from women with documented Zika virus infection (confirmed infection group) and 28 fetuses or neonates from women with presumed cases of Zika virus (presumed infection group). From June 2015 to May 2016, their mothers had been referred to the Instituto de Pesquisa in Campina Grande State Paraiba, a center for high-risk pregnancy in northeastern Brazil where congenital Zika infection has been particularly severe, because either a rash occurred during pregnancy or a fetal central nervous system abnormality was suspected.

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