There is still a good deal of difference of opinion among those best informed as to the type and method of biopsy and as to prebiopsy and postbiopsy irradiation in breast tumors.
I have been observing the results in all breast tumors in which the tumor has been explored first. The object of this exploration was to determine its pathologic nature. Up to 1915 in the Halsted Clinic at Johns Hopkins, the naked-eye diagnosis had been depended on. In my own experience since 1915 I have used naked-eye diagnosis in every case, but, in addition, an immediate frozen section for microscopic study was resorted to in the operating room, and the operation or treatment that followed rested largely on the diagnosis made on this immediate frozen section.
Great changes have been observed and recorded by me since the first exploration that I witnessed on a borderline breast tumor more than
BLOODGOOD JC. BORDERLINE BREAST TUMORSBIOPSY AND POSTBIOPSY TREATMENT. JAMA. 1935;104(6):439–445. doi:10.1001/jama.1935.02760060007002