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Comment & Response
October 25, 2016

Colorectal Cancer Screening

Author Affiliations
  • 1Department of Medicine, Sørlandet Hospital Kristiansand, Kristiansand, Norway
  • 2Department of Medicine, Telemark Hospital, Skien, Norway
  • 3Institute of Health and Society, University of Oslo, Oslo, Norway
JAMA. 2016;316(16):1714. doi:10.1001/jama.2016.13846

To the Editor To inform the recently updated guidelines from the US Preventive Services Task Force (USPSTF) on colorectal cancer (CRC) screening,1 Dr Lin and colleagues conducted a meta-analysis of randomized trials of different screening interventions, including flexible sigmoidoscopy.2 Unfortunately, the authors pooled different age groups in the Norwegian Colorectal Cancer Prevention Trial (NORCCAP)3 to calculate the summary mortality estimate for flexible sigmoidoscopy screening. Methodologically, we do not think this approach is correct because pooling the age groups introduced confounding by age.

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