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Comment & Response
October 25, 2016

Breast Cancer Risk After Ovarian Stimulation for In Vitro Fertilization—Reply

Author Affiliations
  • 1Department of Epidemiology and Biostatistics, The Netherlands Cancer Institute, Amsterdam, the Netherlands
  • 2Department of Obstetrics and Gynecology, Erasmus Medical Center, Rotterdam, the Netherlands
JAMA. 2016;316(16):1713-1714. doi:10.1001/jama.2016.15243

In Reply Dr Tomao and colleagues are concerned that our results may be biased because, for 23% of the study population, information on subfertility diagnosis and number of IVF cycles was obtained from a self-administered questionnaire when medical records were not available. We felt confident using questionnaire data for subfertility diagnosis to limit the amount of missing data because de Boer and colleagues1 reported that in the same study population, the validity of self-reported subfertility causes was satisfactory.

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