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This monograph represents an integration and summary of the author's work on the subject during the' past twenty-five years. A leading thought throughout the treatise is the mechanistic theory of arteriosclerosis. The author believes that normal intravascular pressure is an indispensable factor in the production of sclerosis. He does not deny the presence of other conditioning factors, such as the chemical composition of the blood, vascular supply of the walls of the vessels, intravascular stresses and perivascular resistance. But he maintains that the primary factor is intravascular pressure, which operates not only in arteries but in the entire vascular tree, such as veins, capillaries and the chambers of the heart. Normal or exaggerated function thus precedes morphologic changes, the reaction of the vessels to tension. Evidence is submitted that essential hypertension precedes arteriosclerosis and that arteriocapillary fibrosis in many visceral organs is the result of increased tension. The prophylaxis and
Vascular Sclerosis with Special Reference to Arteriosclerosis: Pathology, Pathogenesis, Etiology, Diagnosis, Prognosis, Treatment. JAMA. 1942;120(2):164. doi:10.1001/jama.1942.02830370076032