September 12, 1942

Vascular Sclerosis with Special Reference to Arteriosclerosis: Pathology, Pathogenesis, Etiology, Diagnosis, Prognosis, Treatment

Author Affiliations

By Eli Moschcowitz, A.B., M.D., Assistant Clinical Professor of Medicine, College of Physicians and Surgeons, Columbia University, New York. Cloth. Price, $3.75. Pp. 178, with 43 illustrations. New York, Toronto & London: Oxford University Press, 1942.

JAMA. 1942;120(2):164. doi:10.1001/jama.1942.02830370076032

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This monograph represents an integration and summary of the author's work on the subject during the' past twenty-five years. A leading thought throughout the treatise is the mechanistic theory of arteriosclerosis. The author believes that normal intravascular pressure is an indispensable factor in the production of sclerosis. He does not deny the presence of other conditioning factors, such as the chemical composition of the blood, vascular supply of the walls of the vessels, intravascular stresses and perivascular resistance. But he maintains that the primary factor is intravascular pressure, which operates not only in arteries but in the entire vascular tree, such as veins, capillaries and the chambers of the heart. Normal or exaggerated function thus precedes morphologic changes, the reaction of the vessels to tension. Evidence is submitted that essential hypertension precedes arteriosclerosis and that arteriocapillary fibrosis in many visceral organs is the result of increased tension. The prophylaxis and

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