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Article
June 16, 1928

INTRAMUSCULAR USE OF CONVALESCENT SERUM IN TREATMENT OF POLIOMYELITIS

Author Affiliations

SAN FRANCISCO
From the Department of Pediatrics, University of California, and the Children's Hospital.

JAMA. 1928;90(24):1923-1927. doi:10.1001/jama.1928.02690510007002
Abstract

In a previous communication,1 the use of convalescent serum intramuscularly in the treatment of a small series of cases of early poliomyelitis was reported. Our purpose in this paper is to report the results of such treatment as employed in a series of eighty-one cases.

There is enough evidence2 at hand to support the view that convalescent serum has definite therapeutic usefulness in poliomyelitis. Most observers, however, have emphasized the value of using such serum intraspinally, with intravenous or intramuscular injection as a less valuable adjuvant. The late E. Charles Fleischner, on the other hand, insisted that on both theoretical and practical grounds the intramuscular route was to be preferred as a means of making the serum quickly and safely available to the early lesion.

Certainly there are definite difficulties in the use of serum intraspinally against which the value of the method must be weighed. It has

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