[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
September 19, 1942


Author Affiliations

Winnetka, Ill.

JAMA. 1942;120(3):227. doi:10.1001/jama.1942.02830380059028

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


To the Editor:—  In the article of Drs. William O. Russell and William C. Stahl (The Journal, August 8, p. 1177) reporting a case of fatal poisoning from potassium thiocyanate treatment of hypertension they write repeatedly of an "accepted therapeutic dose," "the usually prescribed amount of the drug," "the standard and accepted therapeutic dose," "the usually prescribed dose," "the usually prescribed amount," "the dose of thiocyanate usually prescribed and regarded as safe." The main thesis which Barker developed and has reiterated in all his publications on this subject is that there is no usual, standard or accepted therapeutic dose. Each case is an individual dosage problem depending largely on the age of the patient, the degree of vascular sclerosis, efficiency of renal function, the increment of blood thiocyanate concentration over a short period of time and the presence or absence of congestive heart failure. In examining the protocol of this

First Page Preview View Large
First page PDF preview
First page PDF preview