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September 19, 1942


Author Affiliations

Instructor in Biochemistry, Johns Hopkins University School of Hygiene and Public Health.
Associate Professor of Medicine, University of Maryland School of Medicine and College of Physicians and Surgeons. Baltimore.

JAMA. 1942;120(3):227. doi:10.1001/jama.1942.02830380059030

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To the Editor:—  We have read the communication by Dr. Joseph C. Aub and Dr. Lawrence T. Fairhall (The Journal, Jan. 24, 1942, p. 319) in which the view is expressed that silver is not excreted in the urine. Since the comparatively non-strategic nature of silver has encouraged its industrial use during the emergency to replace some of its lowly but more essential metallic relatives, the subject of silver pharmacology may assume greater importance. We wish to call attention to our report of a case of obscure argyria with argyremia (The Journal, Nov. 17, 1934, p. 1521) in which it was demonstrated spectrographically that under certain conditions, at least, significant amounts of silver may be eliminated from the body by excretion in the urine even three months after the cessation of silver ingestion. However, in an old case of well pigmented argyria in which there had been no abnormal silver

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