To the Editor A study by Dr Walter and colleagues1 found differential associations between a polygenic genetic risk score and BMI across different US birth cohorts. In 2015, we published a study about genetic inheritance and body mass.2 One of our analyses was basically identical to theirs in which the following hypothesis was tested: “… that the genetic influence on body mass is greater among recent cohorts than among earlier ones,” using data from the Health and Retirement Study (HRS).
Liu H, Guo G. Association of a Genetic Risk Score With Body Mass Index. JAMA. 2016;316(17):1826. doi:10.1001/jama.2016.14945