In 1898 Wertheim introduced the principle of extended radical abdominal panhysterectomy for the treatment of carcinoma of the cervix, but this procedure carried with it a high mortality. Good results were obtained only when the disease was discovered in an early stage. Soon after this, radiation was used, x-rays in 1902 and radium in 1906. The early results obtained from x-radiation alone were very poor, owing at least in part to the failure to penetrate the tissues deeply. In fact, the first favorable reports of the treatment of this disease with radiation came from the use of radium alone.
The method most frequently used in applying radium has been that in which it is placed in the uterine canal and in the vagina against the cervix. For the great majority of patients in whom one or both broad ligaments have become involved the central portion of the disease may be
TEAHAN RW, WAMMOCK H, WEATHERWAX J. TREATMENT OF CARCINOMA OF THE CERVIX WITH INTERSTITIAL RADIATION. JAMA. 1942;120(6):423-426. doi:10.1001/jama.1942.02830410011003