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October 10, 1942

SOME CLINICAL USES OF PAPAVERINE IN HEART DISEASE

Author Affiliations

CHICAGO
From the Cardiovascular Department, Michael Reese Hospital.

JAMA. 1942;120(6):434-441. doi:10.1001/jama.1942.02830410022006
Abstract

Papaverine is an opium alkaloid of the benzylisoquinoline group, of low toxicity and non-habit forming.1 At the present time its widest clinical use is in the treatment of conditions associated with smooth muscle spasm, e. g. peripheral vascular embolism,2 pulmonary embolism,3 Raynaud's disease4 and ureteral5 or other types of tubular spasm.

We have recently investigated its action on the dog's heart and have found that it is a powerful and lasting coronary vasodilator,6 that it diminishes considerably the ease with which ventricular fibrillation is induced by faradic or other type of stimulation7 and that after its administration vigorous manual massage of the heart will restore orderly, synergic beating to the fibrillating ventricles.8

Further studies on the dog's heart9 revealed that: 1. Papaverine in large doses depresses auriculoventricular and intraventricular conductivity leading to auriculoventricular and intraventricular block. 2. It decreases or eliminates

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