Proanthocyanidins present in cranberries inhibit adherence of Escherichia coli to uroepithelial cells, which has prompted the investigation of cranberry products as a potential nonantimicrobial strategy to prevent urinary tract infection. In a randomized placebo-controlled clinical trial involving 185 women residing in 21 nursing homes, Juthani-Mehta and colleagues found that compared with placebo capsules, daily administration of oral cranberry capsules (containing proanthocyanidins equivalent to 20 ounces of cranberry juice) for 1 year resulted in no significant difference in the presence of bacteriuria plus pyuria. In an Editorial, Nicolle discusses the lack of evidence to support cranberry products for prevention of urinary tract infection.
Highlights. JAMA. 2016;316(18):1841-1843. doi:10.1001/jama.2015.14575