To the Editor In a prespecified subgroup of adults aged 75 years or older participating in the Systolic Blood Pressure Intervention Trial (SPRINT), Dr Williamson and colleagues1 found a lower rate of cardiovascular events and mortality with intensive lowering of blood pressure compared with standard treatment. Some issues need clarification.
Aspirin use was more common in the intervention group (62%) than in the control group (58%). Was adjustment performed for aspirin use?
Karayiannis C, Phan TG, Srikanth V. Intensive vs Standard Blood Pressure Control for Older Adults. JAMA. 2016;316(18):1920-1921. doi:10.1001/jama.2016.14912