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Research Letter
November 15, 2016

Temporal Changes in the Association Between Modifiable Risk Factors and Coronary Heart Disease Incidence

Author Affiliations
  • 1Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina
  • 2Regeneron Pharmaceuticals, Tarrytown, New York
  • 3Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, Canada
  • 4Department of Mathematics and Statistics, Boston University, Boston, Massachusetts
JAMA. 2016;316(19):2041-2043. doi:10.1001/jama.2016.13614

Diagnosis and control of coronary heart disease (CHD) risk factors have received particular emphasis in guidelines issued since 1977 (blood pressure) and 1985 (lipids).1,2 Yet on a population level, little is known about how these efforts have altered CHD incidence and its association with modifiable risk factors. This study explored (1) how the associations between modifiable risk factors and CHD events changed from 1983 through 1995 and from 1996 through 2011, and (2) during this timeframe, whether the population attributable fractions (PAFs) of CHD due to modifiable risk factors were altered.

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