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April 20, 1935


Author Affiliations

From the H. K. Cushing Laboratory of Experimental Medicine, Department of Medicine, Western Reserve University School of Medicine, and the Medical Service, Lakeside Hospital.

JAMA. 1935;104(16):1377-1380. doi:10.1001/jama.1935.02760160001001

It has been known for a long time that pellagra is characterized by remissions and relapses and that the mild cases promptly improve after the assimilation of an adequate diet. Goldberger and his co-workers,1 have produced, prevented and sometimes cured pellagra and have recommended yeast as a specific therapeutic agent.1c Many diets, drugs and minerals have been advocated by others as certain cures for the disease.2 In spite of the application of these recommended methods of treatment, all workers agree that the prognosis is very grave for the severely ill pellagrin and that the mortality rate in the advanced stages of the disease is extremely high. It was shown in a previous publication3 that the mortality rate in a series of seventy-three cases of pellagra was 54 per cent, despite the fact that all of the patients were given hospital care and offered a highly nutritious

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