In a previous paper we described infections arising in rabbits following intranasal inoculation with pneumococci. It was then stated that about 75 per cent of the rabbits became infected following this procedure and that about 50 per cent of those infected recovered after several days.
The recovered rabbits offered splendid material for a study of any altered reaction capacity caused by the Infection, which occurred in a rather natural way and ran a self-limited course. We have accordingly tested these rabbits for hypersensitiveness to the products of pneumococci. An autolysate was prepared similar to the one described by Zinsser and Grinnell.1
It has been found that rabbits which have recovered from the infection are highly sensitive to the autolysate. A small dose (0.2 cc.) injected into the skin gives rise to a very pronounced reaction, which consists of erythema, edema and necrosis. The lesion begins to develop
Bull CG, McKee CM. SENSITIZATION OF RABBITS TO PNEUMOCOCCUS. AUTOLYSATE AS A RESULT OF INFECTION WITH THIS ORGANISM: PRELIMINARY REPORT. JAMA. 1928;91(6):396. doi:10.1001/jama.1928.92700060003010c