[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.166.74.94. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
August 11, 1928

NATURAL VACCINATION AND ITS INFLUENCE ON THE COURSE OF EPIDEMICS, WITH PARTICULAR REFERENCE TO BUBONIC PLAGUE

Author Affiliations

Suez, Egypt. Chief, Bacteriological Service, International Quarantine Board of Egypt.

JAMA. 1928;91(6):416. doi:10.1001/jama.1928.02700060050030

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

To the Editor:  —Preceding or accompanying an outbreak of human plague, a similar outbreak occurs among rodents. A mild epidemic may suddenly be transformed into a more severe type, or a severe one may be reverted into a milder form. Mixed types occur, depending on individual susceptibility. Observations made in Egypt deal with the mechanism involved in such transformations, the rôle of the bacteriophage, the mechanism by which rats acquire a natural immunity to the disease without visible symptoms, and the sudden disappearance of severe symptoms in those having the illness (abortive cases). The latter fact has been proved to be due to the presence of a bacteriophage, thus confirming the general statement of d'Herelle that the bacteriophage is concerned in recovery.Furthermore, it has been found that, prior to an outbreak in rats, little variation in individual susceptibility is seen, while during the epidemic great differences are noted and

First Page Preview View Large
First page PDF preview
First page PDF preview
×