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Since January, 1930, "Avertin" has been the general anesthetic of choice in the neurosurgical service of the Cleveland Clinic Hospital. This anesthetic has been employed in 130 neurosurgical operations with the most gratifying results and with no undesirable effects. The dosage has been as a routine the same, 100 mg. of "Avertin" per kilogram of body weight.
As far as can be determined clinically, "Avertin" apparently does not cause as great an increase in intracranial tension as do other general anesthetics, although it has been shown by spinal puncture that there is some increase in pressure following its administration. Also it has been observed that when "Avertin" was used as an anesthetic in encephalography, the ventricles occasionally failed to empty, even though there was no clinical evidence of obstruction in the ventricular system. It is possible that this failure of the ventricles to empty is due to an intracranial vascular
Gardner WJ, Lamb CA. EFFECT OF "AVERTIN" ON THE CEREBROSPINAL FLUID PRESSURE. JAMA. 1931;96(25):2102–2103. doi:10.1001/jama.1931.27220510003008b