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December 12, 1942


JAMA. 1942;120(15):1218-1219. doi:10.1001/jama.1942.02830500048014

Crystallization of a protein from brains of mice infected with poliomyelitis that has all the infectious properties of poliomyelitis virus has just been reported by Racker1 of the Department of Physiology, University of Minnesota. Twelve years ago Clark and his co-workers2 of the University of Wisconsin reported evidence that the virus of poliomyelitis is found largely in the water soluble globulin fraction of brain-cord suspension infected with poliomyelitis. They showed3 that the virus is not precipitated to any appreciable degree by one-third saturation with ammonium sulfate. Half saturation, however, precipitates it almost quantitatively. Somewhat later Howitt,4 Clifton5 and others found that lipoids can be extracted from infected brain suspensions by means of ether without appreciable decrease in the original infectious titer. After prolonged freezing, Loring and Schwerdt6 of Stanford University afterward isolated a noncrystalline macro-molecular infectious protein from medulla-cord suspensions infected with poliomyelitis by

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