Relative fragility of skin capillaries is a common condition.1 It may be found in individuals of all ages who are otherwise free of signs or symptoms of scurvy. Nevertheless, increase in the antiscorbutic value of the diet of such individuals increases their capillary resistance. This borderland nutritional disorder has been called subclinical scurvy, and a general experience with experimental nutritional diseases suggests that other slight deviations from health are probably present in such persons. The condition is therefore deserving of study. The influence of cevitamic acid on this condition forms the basis of the present report.
The cevitamic acid used was Cebione, Merck & Co. The product was assayed against a standard iodine solution by Harris's method2 and found to be pure within the limits of error of the method. The acid was administered intravenously, 100 mg. being dissolved in at least 10 cc. of distilled water
DALLDORF G, RUSSELL H. THE EFFECT OF CEVITAMIC ACID INJECTIONS ON CAPILLARY RESISTANCE. JAMA. 1935;104(19):1701-1702. doi:10.1001/jama.1935.02760190021006