Ophthalmologists for over twenty years have used nonspecific proteins in the treatment of certain eye diseases. The height of fever produced has served, at least in part, as a guide to the degree of the reaction. In the use of typhoid vaccine, Howard noted several years ago that fever was essential to a good result. In the last year my associates and I have had an opportunity to use artificial fever alone as a means of therapy in a sufficient number of eye conditions to warrant reporting the results thereby obtained.
Kettering hypertherm1 machines were installed more than a year ago in our clinic for experimental work in the treatment of syphilis (principally neurosyphilis), multiple sclerosis, gonorrhea, pelvic peritonitis and arthritis. This apparatus consists of an air conditioned cabinet with which the patient's temperature can be elevated rapidly and maintained at a desired level and carefully controlled for an
WHITNEY EL. ARTIFICIAL FEVER THERAPY IN THE TREATMENT OF CORNEAL ULCER AND ACUTE IRITISPRELIMINARY REPORT. JAMA. 1935;104(20):1794–1797. doi:10.1001/jama.1935.02760200016004