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January 16, 1943

CLINICAL USE OF AMINO ACIDS FOR THE MAINTENANCE OF NITROGEN EQUILIBRIUM

Author Affiliations

DETROIT

From William J. Seymour Hospital, Eloise, Mich., and Wayne University College of Medicine, Detroit.

JAMA. 1943;121(3):163-167. doi:10.1001/jama.1943.02840030001001
Abstract

It has previously been shown that a mixture containing all the essential amino acids can be administered parenterally without untoward effect, that amino acid mixtures so administered may be substituted for protein in the diet and that by this means a patient may be maintained in nitrogen equilibrium.1 It has also been shown that the solution may be administered at the rate of 1 to 2 Gm. of amino acid nitrogen an hour and that, so administered, over 95 per cent of the amino acids was utilized in patients with malignant growths, hyperthyroidism, hypothyroidism, chronic infections, chronic nephritis or cirrhosis of the liver.2

The present study was undertaken to extend the types of conditions in which solution of amino acids may be profitably used and also to observe the effect of this amino acid solution on the blood protein and blood amino acid level. The solution was administered

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