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September 8, 1928


Author Affiliations


JAMA. 1928;91(10):720-722. doi:10.1001/jama.1928.02700100032009

Aplastic anemia is a disease which is rarely observed by the general practitioner. As a type of anemia, however, it is relatively common and very important. It is often overlooked or misdiagnosed because of its varied and striking manifestations, which frequently mask completely the primary illness and cause it to be classed with other diseases, such as the infections or the hemorrhagic diseases.

Aplastic anemia, as described originally by Ehrlich, is caused primarily by aplasia of the bone marrow. As a sequence, the rate of blood generation is reduced and anemia inevitably follows.

Aplastic anemia has been produced experimentally in animals through the agency of benzene poisoning1 and by irradiation of animals.2 Aplasia of the marrow in the wing bones of pigeons follows simple starvation, according to Bizzozero and Torre, Doan3 and Sabin,4 and marrow necrosis can be produced with diphtheria toxin (not antitoxin5). The

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